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MEAF6 Blocking Peptide (C-Term)

Synthetic peptide

     
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Product Information
Primary Accession Q9HAF1
Other Accession Q58CU0, Q2VPQ9
Additional Information
Gene ID 64769
Other Names Chromatin modification-related protein MEAF6, MYST/Esa1-associated factor 6, Esa1-associated factor 6 homolog, Protein EAF6 homolog, hEAF6, Sarcoma antigen NY-SAR-91, MEAF6, C1orf149, EAF6
Target/Specificity The synthetic peptide sequence is selected from aa 140-154 of HUMAN MEAF6
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name MEAF6 (HGNC:25674)
Function Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity.
Cellular Location Nucleus, nucleolus. Chromosome, centromere, kinetochore
Research Areas
Citations (0)

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Background

Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity.

References

Bechtel S.,et al.BMC Genomics 8:399-399(2007).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Lin L.,et al.Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
Gregory S.G.,et al.Nature 441:315-321(2006).
Lee S.-Y.,et al.Proc. Natl. Acad. Sci. U.S.A. 100:2651-2656(2003).

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$ 80.00
Cat# BP21990b
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