SPTBN1 Blocking Peptide (C-Term)
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q01082 |
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Other Accession | Q62261 |
Gene ID | 6711 |
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Other Names | Spectrin beta chain, non-erythrocytic 1, Beta-II spectrin, Fodrin beta chain, Spectrin, non-erythroid beta chain 1, SPTBN1, SPTB2 |
Target/Specificity | The synthetic peptide sequence is selected from aa 2083-2097 of HUMAN SPTBN1 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | SPTBN1 |
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Synonyms | SPTB2 |
Function | Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane. Plays a critical role in central nervous system development and function. |
Cellular Location | Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q62261}. Cytoplasm, myofibril, sarcomere, M line {ECO:0000250|UniProtKB:Q62261}. Cytoplasm, cytosol. Cell membrane. Note=Colocalizes with ANK2 in a distinct intracellular compartment of neonatal cardiomyocytes {ECO:0000250|UniProtKB:Q62261} |
Tissue Location | Isoform 2 is present in brain, lung and kidney (at protein level). |
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Provided below are standard protocols that you may find useful for product applications.
Background
Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane.
References
Hu R.J.,et al.J. Biol. Chem. 267:18715-18722(1992).
Chen Y.,et al.J. Mol. Neurosci. 17:59-70(2001).
Totoki Y.,et al.Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
Hillier L.W.,et al.Nature 434:724-731(2005).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
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