|Other Accession||P14099, Q922S4, Q01062|
|Other Names||cGMP-dependent 3', 5'-cyclic phosphodiesterase, 188.8.131.52, Cyclic GMP-stimulated phosphodiesterase, CGS-PDE, cGSPDE, PDE2A|
|Target/Specificity||The synthetic peptide sequence is selected from aa 807-821 of HUMAN PDE2A|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Cyclic nucleotide phosphodiesterase with a dual- specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Plays an important role in growth and invasion of malignant melanoma cells (e.g. pseudomyxoma peritonei (PMP) cell line) (PubMed:24705027).|
|Cellular Location||Isoform PDE2A3: Cell membrane; Lipid- anchor Isoform PDE2A1: Cytoplasm|
|Tissue Location||Expressed in brain and to a lesser extent in heart, placenta, lung, skeletal muscle, kidney and pancreas|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Cyclic nucleotide phosphodiesterase with a dual- specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes.
Rosman G.J.,et al.Gene 191:89-95(1997).
Bugaj-Gaweda B.,et al.Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Taylor T.D.,et al.Nature 440:497-500(2006).
Russwurm C.,et al.J. Biol. Chem. 284:25782-25790(2009).
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