|Other Names||Microtubule-associated tumor suppressor 1, AT2 receptor-binding protein, Angiotensin-II type 2 receptor-interacting protein, Mitochondrial tumor suppressor 1, MTUS1, ATBP, ATIP, GK1, KIAA1288, MTSG1|
|Target/Specificity||The synthetic peptide sequence is selected from aa 1003-1017 of HUMAN MTUS1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||ATBP, ATIP, GK1, KIAA1288, MTSG1|
|Function||Cooperates with AGTR2 to inhibit ERK2 activation and cell proliferation. May be required for AGTR2 cell surface expression. Together with PTPN6, induces UBE2V2 expression upon angiotensin-II stimulation. Isoform 1 inhibits breast cancer cell proliferation, delays the progression of mitosis by prolonging metaphase and reduces tumor growth.|
|Cellular Location||Mitochondrion. Golgi apparatus. Cell membrane. Nucleus. Note=In neurons, translocates into the nucleus after treatment with angiotensin-II.|
|Tissue Location||Ubiquitously expressed (at protein level). Highly expressed in brain. Down-regulated in ovarian carcinoma, pancreas carcinoma, colon carcinoma and head and neck squamous cell carcinoma (HNSCC). Isoform 1 is the major isoform in most peripheral tissues. Isoform 2 is abundant in most peripheral tissues. Isoform 3 is the major isoform in brain, female reproductive tissues, thyroid and heart. Within brain it is highly expressed in corpus callosum and pons. Isoform 6 is brain- specific, it is the major isoform in cerebellum and fetal brain|
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Provided below are standard protocols that you may find useful for product applications.
Cooperates with AGTR2 to inhibit ERK2 activation and cell proliferation. May be required for AGTR2 cell surface expression. Together with PTPN6, induces UBE2V2 expression upon angiotensin-II stimulation. Isoform 1 inhibits breast cancer cell proliferation, delays the progression of mitosis by prolonging metaphase and reduces tumor growth.
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Seibold S.,et al.FASEB J. 17:1180-1182(2003).
Nouet S.,et al.J. Biol. Chem. 279:28989-28997(2004).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
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