|Other Names||Protein HEXIM2, Hexamethylene bis-acetamide-inducible protein 2, HEXIM2|
|Target/Specificity||The synthetic peptide sequence is selected from aa 255-269 of HUMAN HEXIM2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor. In cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation.|
|Tissue Location||Ubiquitously expressed with higher expression in testis. HEXIM1 and HEXIM2 are differentially expressed|
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Provided below are standard protocols that you may find useful for product applications.
Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor. In cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation.
Petroziello J.,et al.Oncogene 23:7734-7745(2004).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Byers S.A.,et al.J. Biol. Chem. 280:16360-16367(2005).
Yik J.H.N.,et al.J. Biol. Chem. 280:16368-16376(2005).
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