DPYD Blocking Peptide (C-Term)
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q12882 |
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Other Accession | Q5R895 |
Gene ID | 1806 |
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Other Names | Dihydropyrimidine dehydrogenase [NADP(+)], DHPDHase, DPD, 1.3.1.2, Dihydrothymine dehydrogenase, Dihydrouracil dehydrogenase, DPYD |
Target/Specificity | The synthetic peptide sequence is selected from aa 861-875 of HUMAN DPYD |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | DPYD (HGNC:3012) |
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Function | Involved in pyrimidine base degradation (PubMed:1512248). Catalyzes the reduction of uracil and thymine (PubMed:1512248). Also involved the degradation of the chemotherapeutic drug 5-fluorouracil (PubMed:1512248). |
Cellular Location | Cytoplasm. |
Tissue Location | Found in most tissues with greatest activity found in liver and peripheral blood mononuclear cells |
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Provided below are standard protocols that you may find useful for product applications.
Background
Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine. Also involved the degradation of the chemotherapeutic drug 5-fluorouracil.
References
Yokota H.,et al.J. Biol. Chem. 269:23192-23196(1994).
Johnson M.R.,et al.Cancer Res. 57:1660-1663(1997).
Ogura K.,et al.Cancer Lett. 122:107-113(1998).
Kalnine N.,et al.Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
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