|Other Names||Dihydropyrimidine dehydrogenase [NADP(+)], DHPDHase, DPD, 126.96.36.199, Dihydrothymine dehydrogenase, Dihydrouracil dehydrogenase, DPYD|
|Target/Specificity||The synthetic peptide sequence is selected from aa 861-875 of HUMAN DPYD|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine. Also involved the degradation of the chemotherapeutic drug 5-fluorouracil.|
|Tissue Location||Found in most tissues with greatest activity found in liver and peripheral blood mononuclear cells|
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Provided below are standard protocols that you may find useful for product applications.
Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine. Also involved the degradation of the chemotherapeutic drug 5-fluorouracil.
Yokota H.,et al.J. Biol. Chem. 269:23192-23196(1994).
Johnson M.R.,et al.Cancer Res. 57:1660-1663(1997).
Ogura K.,et al.Cancer Lett. 122:107-113(1998).
Kalnine N.,et al.Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
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