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GAS6 Blocking Peptide (Center)

Synthetic peptide

     
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Product Information
Primary Accession Q14393
Additional Information
Gene ID 2621
Other Names Growth arrest-specific protein 6, GAS-6, AXL receptor tyrosine kinase ligand, GAS6, AXLLG
Target/Specificity The synthetic peptide sequence is selected from aa 262-275 of HUMAN GAS6
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name GAS6
Synonyms AXLLG
Function Ligand for tyrosine-protein kinase receptors AXL, TYRO3 and MER whose signaling is implicated in cell growth and survival, cell adhesion and cell migration. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses.
Cellular Location Secreted.
Tissue Location Plasma. Isoform 1 and isoform 2 are widely expressed. Isoform 1 is the predominant form in spleen
Research Areas
Citations (0)

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Background

Ligand for tyrosine-protein kinase receptors AXL, TYRO3 and MER whose signaling is implicated in cell growth and survival, cell adhesion and cell migration. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses.

References

Manfioletti G.,et al.Mol. Cell. Biol. 13:4976-4985(1993).
Munoz X.,et al.Hum. Mutat. 23:506-512(2004).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Dunham A.,et al.Nature 428:522-528(2004).
Maree A.O.,et al.Submitted (OCT-2002) to the EMBL/GenBank/DDBJ databases.

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$ 80.00
Cat# BP22089c
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