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GALC Blocking Peptide (N-Term)

Synthetic peptide

     
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Product Information
Primary Accession P54803
Other Accession P54804, O02791, P54818
Additional Information
Gene ID 2581
Other Names Galactocerebrosidase, GALCERase, 3.2.1.46, Galactocerebroside beta-galactosidase, Galactosylceramidase, Galactosylceramide beta-galactosidase, GALC
Target/Specificity The synthetic peptide sequence is selected from aa 46-56 of HUMAN GALC
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name GALC
Function Hydrolyzes the galactose ester bonds of galactosylceramide, galactosylsphingosine, lactosylceramide, and monogalactosyldiglyceride. Enzyme with very low activity responsible for the lysosomal catabolism of galactosylceramide, a major lipid in myelin, kidney and epithelial cells of small intestine and colon.
Cellular Location Lysosome.
Tissue Location Detected in urine. Detected in testis, brain and placenta (at protein level). Detected in kidney and liver
Research Areas
Citations (0)

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Background

Hydrolyzes the galactose ester bonds of galactosylceramide, galactosylsphingosine, lactosylceramide, and monogalactosyldiglyceride. Enzyme with very low activity responsible for the lysosomal catabolism of galactosylceramide, a major lipid in myelin, kidney and epithelial cells of small intestine and colon.

References

Luzi P.,et al.Genomics 26:407-409(1995).
Sakai N.,et al.Biochim. Biophys. Acta 1395:62-67(1998).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Heilig R.,et al.Nature 421:601-607(2003).
Chen Y.Q.,et al.Hum. Mol. Genet. 2:1841-1845(1993).

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$ 80.00
Cat# BP22090a
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