|Other Names||Equilibrative nucleoside transporter 2, 36 kDa nucleolar protein HNP36, Delayed-early response protein 12, Equilibrative nitrobenzylmercaptopurine riboside-insensitive nucleoside transporter, Equilibrative NBMPR-insensitive nucleoside transporter, Hydrophobic nucleolar protein, 36 kDa, Nucleoside transporter, ei-type, Solute carrier family 29 member 2, SLC29A2, DER12, ENT2, HNP36|
|Target/Specificity||The synthetic peptide sequence is selected from aa 1-11 of HUMAN SLC29A2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||DER12, ENT2, HNP36|
|Function||Mediates equilibrative transport of purine, pyrimidine nucleosides and the purine base hypoxanthine. Very less sensitive than SLC29A1 to inhibition by nitrobenzylthioinosine (NBMPR), dipyridamole, dilazep and draflazine.|
|Cellular Location||Basolateral cell membrane; Multi-pass membrane protein. Nucleus membrane; Multi-pass membrane protein. Note=Localized at the basolateral cell membrane in polarized MDCK cells|
|Tissue Location||Expressed in skeletal muscle, liver, lung, placenta, brain, heart, kidney and ovarian tissues|
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Mediates equilibrative transport of purine, pyrimidine nucleosides and the purine base hypoxanthine. Very less sensitive than SLC29A1 to inhibition by nitrobenzylthioinosine (NBMPR), dipyridamole, dilazep and draflazine.
Williams J.B.,et al.Biochem. Biophys. Res. Commun. 213:325-333(1995).
Griffiths M.,et al.Biochem. J. 328:739-743(1997).
Crawford C.R.,et al.J. Biol. Chem. 273:5288-5293(1998).
Mangravite L.M.,et al.Am. J. Physiol. 284:F902-F910(2003).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
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