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ZDHHC18 Blocking Peptide (C-Term)
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9NUE0 |
|---|---|
| Other Accession | Q5Y5T2, Q2TGJ1 |
| Gene ID | 84243 |
|---|---|
| Other Names | Palmitoyltransferase ZDHHC18, 2.3.1.225, Zinc finger DHHC domain-containing protein 18, DHHC-18, ZDHHC18 |
| Target/Specificity | The synthetic peptide sequence is selected from aa 351-361 of HUMAN ZDHHC18 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | ZDHHC18 {ECO:0000303|PubMed:35438208, ECO:0000312|HGNC:HGNC:20712} |
|---|---|
| Function | Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates, such as CGAS, HRAS and LCK (PubMed:23034182, PubMed:27481942, PubMed:35438208). Acts as a negative regulator of the cGAS-STING pathway be mediating palmitoylation and inactivation of CGAS (PubMed:35438208). May also have a palmitoyltransferase activity toward the beta-2 adrenergic receptor/ADRB2 and therefore regulate G protein-coupled receptor signaling (PubMed:27481942). |
| Cellular Location | Golgi apparatus membrane; Multi-pass membrane protein |
| Tissue Location | Widely expressed.. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Has palmitoyltransferase activity towards HRAS and LCK.
References
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Gregory S.G.,et al.Nature 441:315-321(2006).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
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