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ARHGEF7 Blocking Peptide (C-Term)

Synthetic peptide

     
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Product Information
Primary Accession Q14155
Other Accession Q9ES28
Additional Information
Gene ID 8874
Other Names Rho guanine nucleotide exchange factor 7, Beta-Pix, COOL-1, PAK-interacting exchange factor beta, p85, ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
Target/Specificity The synthetic peptide sequence is selected from aa 674-688 of HUMAN ARHGEF7
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name ARHGEF7
Synonyms COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
Function Acts as a RAC1 guanine nucleotide exchange factor (GEF) and can induce membrane ruffling. Functions in cell migration, attachment and cell spreading. Promotes targeting of RAC1 to focal adhesions (By similarity). May function as a positive regulator of apoptosis. Downstream of NMDA receptors and CaMKK-CaMK1 signaling cascade, promotes the formation of spines and synapses in hippocampal neurons.
Cellular Location Cell junction, focal adhesion. Cell projection, ruffle. Cytoplasm, cell cortex. Cell projection, lamellipodium Note=Detected at cell adhesions. A small proportion is detected at focal adhesions
Research Areas
Citations (0)

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Background

Acts as a RAC1 guanine nucleotide exchange factor (GEF) and can induce membrane ruffling. Functions in cell migration, attachment and cell spreading. Promotes targeting of RAC1 to focal adhesions (By similarity). May function as a positive regulator of apoptosis. Downstream of NMDA receptors and CaMKK-CaMK1 signaling cascade, promotes the formation of spines and synapses in hippocampal neurons.

References

Nagase T.,et al.DNA Res. 2:167-174(1995).
Bagrodia S.,et al.J. Biol. Chem. 273:23633-23636(1998).
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
Dunham A.,et al.Nature 428:522-528(2004).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.

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$ 80.00
Cat# BP22153b
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