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DBN1 Blocking Peptide (Center)

Synthetic peptide

     
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Product Information
Primary Accession Q16643
Other Accession Q9QXS6, Q07266
Additional Information
Gene ID 1627
Other Names Drebrin, Developmentally-regulated brain protein, DBN1, D0S117E
Target/Specificity The synthetic peptide sequence is selected from aa 214-228 of HUMAN DBN1
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name DBN1
Synonyms D0S117E
Function Drebrins might play some role in cell migration, extension of neuronal processes and plasticity of dendrites. Required for actin polymerization at immunological synapses (IS) and for CXCR4 recruitment to IS.
Cellular Location Cytoplasm. Cytoplasm, cell cortex. Cell junction. Cell projection {ECO:0000250|UniProtKB:Q9QXS6}. Cell projection, growth cone {ECO:0000250|UniProtKB:Q9QXS6}. Note=In the absence of antigen, evenly distributed throughout subcortical regions of the T-cell membrane and cytoplasm. In the presence of antigen, distributes to the immunological synapse forming at the T-cell-APC contact area, where it localizes at the peripheral and distal supramolecular activation clusters (SMAC) (PubMed:20215400). Colocalized with DBN1, RUFY3 and F-actin at the transitional domain of the axonal growth cone (By similarity). {ECO:0000250|UniProtKB:Q9QXS6, ECO:0000269|PubMed:20215400}
Tissue Location Brain neurons. Also found in the heart, placenta, skeletal muscle, kidney and pancreas. Expressed in peripheral blood lymphocytes, including T-cells (at protein level).
Research Areas
Citations (0)

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Background

Drebrins might play some role in cell migration, extension of neuronal processes and plasticity of dendrites. Required for actin polymerization at immunological synapses (IS) and for CXCR4 recruitment to IS.

References

Toda M.,et al.Biochem. Biophys. Res. Commun. 196:468-472(1993).
Fisher L.W.,et al.Neurosci. Res. Commun. 14:35-42(1994).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
Schmutz J.,et al.Nature 431:268-274(2004).

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$ 80.00
Cat# BP22154c
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