|Other Names||ADP-ribosylation factor-like protein 4D, ADP-ribosylation factor-like protein 4L, ARL4D, ARF4L|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP2302b was selected from the C-term region of human ARF4L . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. Recruits CYTH1, CYTH2, CYTH3 and CYTH4 to the plasma membrane in GDP-bound form.|
|Cellular Location||Nucleus, nucleolus. Cell membrane. Nucleus. Cytoplasm|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
email@example.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
ARF4L is a member of the ADP-ribosylation factor family of GTP-binding proteins. This protein has a nuclear localization signal and an unusually high guanine nucleotide exchange rate. ARF4L may play a role in membrane-associated intracellular trafficking and protein secretion. Mutations in the ARF4L gene have been associated with Bardet-Biedl syndrome (BBS).
Strausberg, R.L., et al., Proc. Natl. Acad. Sci. U.S.A. 99(26):16899-16903 (2002).Smith, S.A., et al., Genomics 28(1):113-115 (1995).
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at firstname.lastname@example.org.