|Other Names||ADP-ribosylation factor-like protein 4A, ARL4A, ARL4|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP2307a was selected from the N-term region of human ARL4 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. Recruits CYTH1, CYTH2, CYTH3 and CYTH4 to the plasma membrane in GDP-bound form.|
|Cellular Location||Cell membrane. Cytoplasm. Nucleus, nucleolus. Note=Localization in the nucleolus is dependent by nucleotide binding|
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Provided below are standard protocols that you may find useful for product applications.
ADP-ribosylation factors (ARFs) regulate intracellular vesicular membrane trafficking and stimulate a phospholipase D isoform. ARL (ADP-ribosylation like factor) proteins are very similar in sequence to ARFs. ARFs and ARF-like (ARL) proteins, which share sequence similarity with ARFs, form a subfamily of the Ras-related GTPase superfamily. A number of experiments from different laboratories have pointed to a role for ARL4 in sperm production. Mice lacking Arl4 do not have upregulated expression of other Arl genes in testis, were viable and exhibited normal fertility, but presented reduced testicular weight and sperm count. It has been proposed that ARL4 is required for the progression of cells through meiosis and that ARL4 deletion retards production of haploid spermatides.
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