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ARL4 Antibody (C-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession P40617
Additional Information
Gene ID 10124
Other Names ADP-ribosylation factor-like protein 4A, ARL4A, ARL4
Target/Specificity The synthetic peptide sequence used to generate the antibody AP2307b was selected from the C-term region of human ARL4 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name ARL4A
Synonyms ARL4
Function Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. Recruits CYTH1, CYTH2, CYTH3 and CYTH4 to the plasma membrane in GDP-bound form.
Cellular Location Cell membrane. Cytoplasm. Nucleus, nucleolus. Note=Localization in the nucleolus is dependent by nucleotide binding
Research Areas
Citations (0)

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ADP-ribosylation factors (ARFs) regulate intracellular vesicular membrane trafficking and stimulate a phospholipase D isoform. ARL (ADP-ribosylation like factor) proteins are very similar in sequence to ARFs. ARFs and ARF-like (ARL) proteins, which share sequence similarity with ARFs, form a subfamily of the Ras-related GTPase superfamily. A number of experiments from different laboratories have pointed to a role for ARL4 in sperm production. Mice lacking Arl4 do not have upregulated expression of other Arl genes in testis, were viable and exhibited normal fertility, but presented reduced testicular weight and sperm count. It has been proposed that ARL4 is required for the progression of cells through meiosis and that ARL4 deletion retards production of haploid spermatides.

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$ 80.00
Cat# BP2307b
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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