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ARL6 Antibody (N-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q9H0F7
Other Accession ARL6_HUMAN
Clone Names 3102709
Peptide ID 3102709
Additional Information
Gene ID 84100
Other Names ADP-ribosylation factor-like protein 6, Bardet-Biedl syndrome 3 protein, ARL6, BBS3
Target/Specificity The synthetic peptide sequence used to generate the antibody AP2309a was selected from the N-term region of human ARL6 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name ARL6
Synonyms BBS3
Function Involved in membrane protein trafficking at the base of the ciliary organelle. Mediates recruitment onto plasma membrane of the BBSome complex which would constitute a coat complex required for sorting of specific membrane proteins to the primary cilia (PubMed:20603001). Together with BBS1, is necessary for correct trafficking of PKD1 to primary cilia (By similarity). Together with the BBSome complex and LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation (PubMed:22072986). May regulate cilia assembly and disassembly and subsequent ciliary signaling events such as the Wnt signaling cascade (PubMed:20207729). Isoform 2 may be required for proper retinal function and organization (By similarity).
Cellular Location Cell projection, cilium membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton, cilium axoneme. Cytoplasm, cytoskeleton, cilium basal body Note=Appears in a pattern of punctae flanking the microtubule axoneme that likely correspond to small membrane-associated patches. Localizes to the so-called ciliary gate where vesicles carrying ciliary cargo fuse with the membrane
Research Areas
Citations (0)

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ARL6 belongs to the ARF family of GTP-binding proteins. ARF proteins are important regulators of cellular traffic and are the founding members of an expanding family of homologous proteins and genomic sequences. They depart from other small GTP-binding proteins by a unique structural device that implements front-back communication from the N-terminus to the nucleotide-binding site. Studies of the mouse ortholog of this protein suggest an involvement in protein transport, membrane trafficking, or cell signaling during hematopoietic maturation. Alternative splicing occurs at this locus and two transcript variants encoding the same protein have been described.


Pasqualato, S., et al., EMBO Rep. 3(11):1035-1041 (2002).Ingley, E., et al., FEBS Lett. 459(1):69-74 (1999).Jacobs, S., et al., FEBS Lett. 456(3):384-388 (1999).

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$ 80.00
Cat# BP2309a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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