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ARL7 Antibody (N-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession P56559
Other Accession NP_005728
Clone Names 3102711
Additional Information
Gene ID 10123
Other Names ADP-ribosylation factor-like protein 4C, ADP-ribosylation factor-like protein 7, ADP-ribosylation factor-like protein LAK, ARL4C, ARL7
Target/Specificity The synthetic peptide sequence used to generate the antibody AP2310a was selected from the N-term region of human ARL7 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name ARL4C
Synonyms ARL7
Function Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase- activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. May be involved in transport between a perinuclear compartment and the plasma membrane, apparently linked to the ABCA1-mediated cholesterol secretion pathway. Recruits CYTH1, CYTH2, CYTH3 and CYTH4 to the plasma membrane in the GDP-bound form. Regulates the microtubule-dependent intracellular vesicular transport from early endosome to recycling endosome process.
Cellular Location Cell projection, filopodium. Cell membrane. Cytoplasm
Tissue Location Expressed in several tumor cell lines (at protein level). Expressed in lung, brain, leukocytes and placenta
Research Areas
Citations (0)
citation

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Background

ADP-ribosylation factor-like 7 is a member of the ADP-ribosylation factor family of GTP-binding proteins. ARL7 is closely similar to ARL4 and ARL6 and each has a nuclear localization signal and an unusually high guanine nucleotide exchange rate.

References

Jacobs, S., et al., FEBS Lett. 456(3):384-388 (1999).

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$ 277.78
Cat# BP2310a
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Availability: 2 weeks
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