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RAGE (AGER) Antibody (C-term) Blocking peptide

Synthetic peptide

Product Information
Primary Accession Q15109
Other Accession RAGE_HUMAN
Clone Names 3102203
Additional Information
Gene ID 177
Other Names Advanced glycosylation end product-specific receptor, Receptor for advanced glycosylation end products, AGER, RAGE
Target/Specificity The synthetic peptide sequence used to generate the antibody AP2401b was selected from the C-term region of human AGER . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms RAGE
Function Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF- alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators. Interaction with S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling (By similarity). Receptor for amyloid beta peptide. Contributes to the translocation of amyloid-beta peptide (ABPP) across the cell membrane from the extracellular to the intracellular space in cortical neurons. ABPP-initiated RAGE signaling, especially stimulation of p38 mitogen-activated protein kinase (MAPK), has the capacity to drive a transport system delivering ABPP as a complex with RAGE to the intraneuronal space. Can also bind oligonucleotides.
Cellular Location Isoform 1: Cell membrane; Single-pass type I membrane protein Isoform 10: Cell membrane; Single-pass type I membrane protein
Tissue Location Endothelial cells.
Research Areas
Citations (0)

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AGER is a member of the immunoglobulin superfamily of cell surface molecules. It is a receptor for various molecules, including the amyloidogenic form of serum amyloid A, amyloid-beta protein, members of the S100/calgranulin superfamily and advanced glycation end products. The gene lies within the major histocompatibility complex (MHC) class III region on chromosome 6.


Schlueter, C., et al., Biochim. Biophys. Acta 1630(1):1-6 (2003).Shanmugam, N., et al., J. Biol. Chem. 278(37):34834-34844 (2003).Kuniyasu, H., et al., Oncol. Rep. 10(2):445-448 (2003).Hsieh, H.L., et al., Biochem. Biophys. Res. Commun. 307(2):375-381 (2003).Rocken, C., et al., Am. J. Pathol. 162(4):1213-1220 (2003).

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$ 80.00
Cat# BP2401b
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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