|Other Names||Alpha-1, 6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase, Beta-1, 2-N-acetylglucosaminyltransferase II, GlcNAc-T II, GNT-II, Mannoside acetylglucosaminyltransferase 2, N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase II, MGAT2|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP2407a was selected from the N-term region of human MGAT2 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Catalyzes an essential step in the conversion of oligo- mannose to complex N-glycans.|
|Cellular Location||Golgi apparatus membrane; Single-pass type II membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
MGAT2 (UDP-N-acetylglucosamine:alpha-6-D-mannoside-beta-1, 2-N-acetylglucosaminyltransferase II) is a Golgi enzyme catalyzing an essential step in the conversion of oligomannose to complex N-glycans. The enzyme has the typical glycosyltransferase domains: a short N-terminal cytoplasmic domain, a hydrophobic non-cleavable signal-anchor domain, and a C-terminal catalytic domain. Mutations in MGAT2 may lead to carbohydrate-deficient glycoprotein syndrome, type II.
Yen, C.L., et al., J. Biol. Chem. 278(20):18532-18537 (2003).Chen, S.H., et al., Glycoconj. J. 15(3):301-308 (1998).Tan, J., et al., Am. J. Hum. Genet. 59(4):810-817 (1996).Tan, J., et al., Eur. J. Biochem. 231(2):317-328 (1995).D'Agostaro, G.A., et al., J. Biol. Chem. 270(25):15211-15221 (1995).
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