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MLP Antibody (Center) Blocking Peptide
Synthetic peptide
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- BACKGROUND
| Primary Accession | P49006 |
|---|---|
| Clone Names | 3092401 |
| Gene ID | 65108 |
|---|---|
| Other Names | MARCKS-related protein, MARCKS-like protein 1, Macrophage myristoylated alanine-rich C kinase substrate, Mac-MARCKS, MacMARCKS, MARCKSL1, MLP, MRP |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP2413b was selected from the Center region of human MLP . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | MARCKSL1 |
|---|---|
| Synonyms | MLP, MRP |
| Function | Controls cell movement by regulating actin cytoskeleton homeostasis and filopodium and lamellipodium formation (PubMed:22751924). When unphosphorylated, induces cell migration (By similarity). When phosphorylated by MAPK8, induces actin bundles formation and stabilization, thereby reducing actin plasticity, hence restricting cell movement, including neuronal migration (By similarity). May be involved in coupling the protein kinase C and calmodulin signal transduction systems (By similarity). |
| Cellular Location | Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:P28667}. Cell membrane; Lipid- anchor. Note=Associates with the membrane via the insertion of the N-terminal N-myristoyl chain and the partial insertion of the effector domain. Association of the effector domain with membranes may be regulated by Ca(2+)/calmodulin. Colocalizes with F-actin at the leading edge of migrating cells (By similarity). In prostate cancers, shows strong expression at apical and/or basal regions of the cell and also has weak cytoplasmic expression (PubMed:22751924). {ECO:0000250|UniProtKB:P28667, ECO:0000269|PubMed:22751924} |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
References
Hsia, T.C., et al., Lung 180(3):173-179 (2002).Stumpo, D.J., et al., Genomics 49(2):253-264 (1998).Umekage, T., et al., FEBS Lett. 286 (1-2), 147-151 (1991).
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