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FNTB Antibody (N-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession P49356
Other Accession NP_002019
Clone Names 3092505
Peptide ID 3092505
Additional Information
Gene ID 100529261;2342
Other Names Protein farnesyltransferase subunit beta, FTase-beta, CAAX farnesyltransferase subunit beta, Ras proteins prenyltransferase subunit beta, FNTB
Target/Specificity The synthetic peptide sequence used to generate the antibody AP2414a was selected from the N-term region of human FNTB . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Function Essential subunit of the farnesyltransferase complex. Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C- terminus of several proteins having the C-terminal sequence Cys- aliphatic-aliphatic-X.
Research Areas
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Eukaryotic cells contain 3 different types of prenyltransferases that attach either a farnesyl group (15 carbons) or a geranylgeranyl group (20 carbons) in thioether linkage to C-terminal cysteine residues in a variety of proteins. These posttranslational modifications provide a mechanism for membrane localization of proteins that lack a transmembrane domain. CAAX farnesyltransferase (FTase) attaches a farnesyl group from farnesyl pyrophosphate to cysteine residues at the fourth position from the C terminus of proteins that end in the CAAX box, where C is cysteine, A is usually but not always an aliphatic amino acid, and X is typically methionine or serine. This enzyme has the ability to farnesylate peptides as short as 4 residues in length that conform to the CAAX consensus sequence. The gene for the beta subunit of CAAX farnesyltransferase (FNTB) has been pinpointed to 14q23-q24 by Southern blot hybridization and PCR analyses of panels of human/Chinese hamster somatic cell hybrid lines and by fluorescence chromosomal in situ hybridization.


Lobell, R.B., et al., Cancer Res. 61(24):8758-8768 (2001).Wang, T., et al., Science 271(5252):1120-1122 (1996).Andres, D.A., et al., Genomics 18(1):105-112 (1993).Omer, C.A., et al., Biochemistry 32(19):5167-5176 (1993).

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$ 80.00
Cat# BP2414a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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