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VNN2 Antibody (C-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession O95498
Clone Names 3092404
Additional Information
Gene ID 8875
Other Names Vascular non-inflammatory molecule 2, Vanin-2, Glycosylphosphatidyl inositol-anchored protein GPI-80, Protein FOAP-4, VNN2
Target/Specificity The synthetic peptide sequence used to generate the antibody AP2422b was selected from the C-term region of human VNN2-L445. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name VNN2
Function Amidohydrolase that hydrolyzes specifically one of the carboamide linkages in D-pantetheine thus recycling pantothenic acid (vitamin B5) and releasing cysteamine. Involved in the thymus homing of bone marrow cells. May regulate beta-2 integrin-mediated cell adhesion, migration and motility of neutrophil.
Cellular Location Cell membrane; Lipid-anchor, GPI-anchor
Tissue Location Widely expressed with higher expression in spleen and blood.
Research Areas
Citations (0)

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VNN2 is a member of the Vanin family of proteins which share extensive sequence similarity with each other, and also with biotinidase. The family includes secreted and membrane-associated proteins, a few of which have been reported to participate in hematopoietic cell trafficking. No biotinidase activity has been demonstrated for any of the vanin proteins, however, they possess pantetheinase activity, which may play a role in oxidative-stress response. The encoded protein is a GPI-anchored cell surface molecule that plays a role in transendothelial migration of neutrophils.


Sasaki, H., et al., Cancer Sci. 94(9):809-813 (2003).Takeda, Y., et al., Exp. Cell Res. 286(2):199-208 (2003).Sendo, D., et al., Immunobiology 207(3):217-221 (2003).Martin, F., et al., Immunogenetics 53(4):296-306 (2001).Suzuki, K., et al., J. Immunol. 162(7):4277-4284 (1999).

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$ 80.00
Cat# BP2422b
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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