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GPI8 Antibody (C-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q92643
Other Accession GPI8_HUMAN
Clone Names 3090610
Peptide ID 3090610
Additional Information
Gene ID 10026
Other Names GPI-anchor transamidase, GPI transamidase, 3---, GPI8 homolog, hGPI8, Phosphatidylinositol-glycan biosynthesis class K protein, PIG-K, PIGK, GPI8
Target/Specificity The synthetic peptide sequence used to generate the antibody AP2462b was selected from the C-term region of human GPI8 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms GPI8
Function Mediates GPI anchoring in the endoplasmic reticulum, by replacing a protein's C-terminal GPI attachment signal peptide with a pre-assembled GPI. During this transamidation reaction, the GPI transamidase forms a carbonyl intermediate with the substrate protein.
Cellular Location Endoplasmic reticulum membrane; Single-pass type I membrane protein
Research Areas
Citations (0)

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GPI8 is a member of the cysteine protease family C13 that is involved in glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor is a glycolipid found on many blood cells and serves to anchor proteins to the cell surface. This protein is a member of the multisubunit enzyme, GPI transamidase and is thought to be its enzymatic component. GPI transamidase mediates GPI anchoring in the endoplasmic reticulum, by catalyzing the transfer of fully assembled GPI units to proteins.


Ohishi, K., et al., J. Biol. Chem. 278(16):13959-13967 (2003).Vainauskas, S., et al., J. Biol. Chem. 277(34):30535-30542 (2002).Ohishi, K., et al., EMBO J. 20(15):4088-4098 (2001).Meyer, U., et al., Biochemistry 39(12):3461-3471 (2000).Yu, J., et al., Proc. Natl. Acad. Sci. U.S.A. 94(23):12580-12585 (1997).

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$ 80.00
Cat# BP2462b
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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