|Other Names||Caprin-1, Cell cycle-associated protein 1, Cytoplasmic activation- and proliferation-associated protein 1, GPI-anchored membrane protein 1, GPI-anchored protein p137, GPI-p137, p137GPI, Membrane component chromosome 11 surface marker 1, RNA granule protein 105, CAPRIN1, GPIAP1, GPIP137, M11S1, RNG105|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP2463a was selected from the N-term region of human GPIP137 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||GPIAP1, GPIP137, M11S1, RNG105|
|Function||May regulate the transport and translation of mRNAs of proteins involved in synaptic plasticity in neurons and cell proliferation and migration in multiple cell types. Binds directly and selectively to MYC and CCND2 RNAs. In neuronal cells, directly binds to several mRNAs associated with RNA granules, including BDNF, CAMK2A, CREB1, MAP2, NTRK2 mRNAs, as well as to GRIN1 and KPNB1 mRNAs, but not to rRNAs.|
|Cellular Location||Cytoplasm, cytosol. Cell projection, dendrite. Note=Associated with RNA granules.|
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Provided below are standard protocols that you may find useful for product applications.
GPIP137, attached to cell membranes via a GPI-anchor, may play a role in transporting nutrient from the gut lumen across the gutlining epithelial cell layer. Expression of this protein is ubiquitous.
J. Immunol. 175 (7), 4274-4282 (2005)J. Biol. Chem. 279 (50), 52210-52217 (2004)J. Immunol. 172 (4), 2389-2400 (2004)Genomics 32 (1), 169-170 (1996)J. Biol. Chem. 270 (35), 20717-20723 (1995)
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