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>   home   >   Products   >   Peptides   >   Blocking Peptides   >   RanGAP1 (Ran-GTPase) Antibody (Sumoylation Site Specific) Blocking peptide   

RanGAP1 (Ran-GTPase) Antibody (Sumoylation Site Specific) Blocking peptide

Synthetic peptide

Product Information
Primary Accession P46060
Other Accession NP_002874
Clone Names 2110407
Peptide ID 2110407
Additional Information
Gene ID 5905
Other Names Ran GTPase-activating protein 1, RanGAP1, RANGAP1, KIAA1835, SD
Target/Specificity The synthetic peptide sequence used to generate the antibody AP2503a was selected from the region of human Ran-GTPase Sumoylation site. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms KIAA1835, SD
Function GTPase activator for the nuclear Ras-related regulatory protein Ran, converting it to the putatively inactive GDP-bound state.
Cellular Location Cytoplasm. Nucleus membrane; Peripheral membrane protein; Cytoplasmic side. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle pole. Note=Cytoplasmic during interphase. Targeted to the nuclear rim after sumoylation. During mitosis, associates with mitotic spindles. Association with kinetochores appears soon after nuclear envelope breakdown and persists until late anaphase Mitotic location also requires sumoylation
Tissue Location Highly expressed in brain, thymus and testis.
Research Areas
Citations (0)

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RanGAP1, is a homodimeric 65-kD polypeptide that specifically induces the GTPase activity of RAN, but not of RAS by over 1,000-fold. RanGAP1 is the immediate antagonist of RCC1, a regulator molecule that keeps RAN in the active, GTP-bound state. The RANGAP1 gene encodes a 587-amino acid polypeptide. The sequence is unrelated to that of GTPase activators for other RAS-related proteins, but is 88% identical to Fug1, the murine homolog of yeast Rna1p. RanGAP1 and RCC1 control RAN-dependent transport between the nucleus and cytoplasm. RanGAP1 is a key regulator of the RAN GTP/GDP cycle.


Bischoff, F.R., et al., Proc. Natl. Acad. Sci. U.S.A. 92(5):1749-1753 (1995).Bischoff, F.R., et al., Proc. Natl. Acad. Sci. U.S.A. 91(7):2587-2591 (1994).Matunis, M.J., et al., J. Cell Biol. 135 (6 Pt 1), 1457-1470 (1996).

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$ 80.00
Cat# BP2503a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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