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ARNT /ARNT2 Antibody Blocking peptide

Synthetic peptide

Product Information
Primary Accession Q9HBZ2
Clone Names 2110601
Peptide ID 2110601
Additional Information
Gene ID 9915
Other Names Aryl hydrocarbon receptor nuclear translocator 2, ARNT protein 2, Class E basic helix-loop-helix protein 1, bHLHe1, ARNT2, BHLHE1, KIAA0307
Target/Specificity The synthetic peptide sequence used to generate the antibody AP2508a is KTGTVKKEGQQSSMRCA containing a predicted sumoylation site from the N-terminal region of human ARNT2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name ARNT2
Synonyms BHLHE1, KIAA0307
Function Transcription factor that plays a role in the development of the hypothalamo-pituitary axis, postnatal brain growth, and visual and renal function (PubMed:24022475). Specifically recognizes the xenobiotic response element (XRE).
Cellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00981}
Research Areas
Citations (0)

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The aryl hydrocarbon (Ah) receptor is involved in the induction of several enzymes that participate in xenobiotic metabolism. The ligand-free, cytosolic form of the Ah receptor is complexed to heat shock protein 90. Binding of ligand, which includes dioxin and polycyclic aromatic hydrocarbons, results intranslocation of the ligand-binding subunit only to the nucleus. Induction of enzymes involved in xenobiotic metabolism occurs through binding of the ligand-bound Ah receptor to xenobiotic responsive elements in the promoters of genes for these enzymes. This gene encodes a protein that forms a complex with the ligand-bound Ah receptor, and is required for receptor function. The encoded protein has also been identified as the beta subunit of a heterodimeric transcription factor, hypoxia-inducible factor 1 (HIF1). A t(1;12)(q21;p13) translocation, which results in a TEL-ARNT fusion protein, is associated with leukemia. Sumoylation of ARNT modulates the ability of ARNT to interact with cooperative molecules such as PML, thereby regulating the transcriptional role of ARNT. This exemplifies a crucial role of protein sumoylation in modulating protein-protein interactions.


Tojo, et al., J Biol Chem. 2002 Nov 29;277(48):46576-85.Barrow, L.L., et al., Teratology 66(2):85-90 (2002).Nagase, T., et al., DNA Res. 4(2):141-150 (1997).

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$ 80.00
Cat# BP2508a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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