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NYREN18 Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9Y5A7 |
|---|---|
| Clone Names | 2120202 |
| Gene ID | 51667 |
|---|---|
| Other Names | NEDD8 ultimate buster 1, Negative regulator of ubiquitin-like proteins 1, Renal carcinoma antigen NY-REN-18, NUB1, NYREN18 |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP2510a was selected from the N-term region of human NYREN18 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | NUB1 |
|---|---|
| Synonyms | NYREN18 |
| Function | Specific down-regulator of the NEDD8 conjugation system. Recruits NEDD8, UBD, and their conjugates to the proteasome for degradation. Isoform 1 promotes the degradation of NEDD8 more efficiently than isoform 2. |
| Cellular Location | Nucleus. Note=Predominantly nuclear |
| Tissue Location | Widely expressed with lowest expression in the pancreas for isoform 1 and in leukocytes, liver, prostate and skeletal muscle for isoform 2 |
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Provided below are standard protocols that you may find useful for product applications.
Background
NYREN18 is a specific down-regulator of the NEDD8 conjugation system. It recruits NEDD8 and its conjugates to the proteasome for degradation. It also interacts with PSMD4/S5a, a member of the regulatory subunit of the 26S proteasome.
References
Tanaka, T., et al., J. Biol. Chem. 278(35):32905-32913 (2003).Strausberg, R.L., et al., Proc. Natl. Acad. Sci. U.S.A. 99(26):16899-16903 (2002).Kito, K., et al., J. Biol. Chem. 276(23):20603-20609 (2001).Kamitani, T., et al., J. Biol. Chem. 276(49):46655-46660 (2001).Scanlan, M.J., et al., Int. J. Cancer 83(4):456-464 (1999).
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