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EZH1 Antibody (Center) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q92800
Clone Names 2120606
Peptide ID 2120606
Additional Information
Gene ID 2145
Other Names Histone-lysine N-methyltransferase EZH1, ENX-2, Enhancer of zeste homolog 1, EZH1, KIAA0388
Target/Specificity The synthetic peptide sequence used to generate the antibody AP2511c was selected from the Center region of human EZH1 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name EZH1
Synonyms KIAA0388
Function Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH1 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Required for embryonic stem cell derivation and self-renewal, suggesting that it is involved in safeguarding embryonic stem cell identity. Compared to EZH2-containing complexes, it is less abundant in embryonic stem cells, has weak methyltransferase activity and plays a less critical role in forming H3K27me3, which is required for embryonic stem cell identity and proper differentiation.
Cellular Location Nucleus. Note=Colocalizes with trimethylated 'Lys-27' of histone H3
Research Areas
Citations (0)

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EZH1 encodes a protein of 747 amino acids that displays 55% amino acid identity overall with the Drosophila homolog.1 The strong sequence conservation suggested potential roles for EZH1 in human development as a transcriptional regulator and as a component of protein complexes that preserve heterochromatin stability. EZH1 is expressed as 2 major transcripts in all adult and fetal human tissues evaluated.. Analysis of an EZH1 cDNA revealed an unusual splicing event involving EZH1 and a tandemly linked gene GPR2 and suggested a potential mechanism for modifying the EZH1 protein in the conserved C-terminal domain. The GPR2 gene maps to 17q21.1-q21.3 in the vicinity of the BRCA1 gene.


Ogawa, M., et al., Biochim. Biophys. Acta 1395(2):151-158 (1998).Abel, K.J., et al., Genomics 37(2):161-171 (1996).Friedman, L.S., et al., Genomics 25(1):256-263 (1995).Osborne-Lawrence, S., et al., Genomics 25(1):248-255 (1995).Brody, L.C., et al., Genomics 25(1):238-247 (1995).

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$ 80.00
Cat# BP2511c
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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