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BMI Antibody (Center) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession P35226
Clone Names 2120609
Additional Information
Gene ID 100532731;648
Other Names Polycomb complex protein BMI-1, Polycomb group RING finger protein 4, RING finger protein 51, BMI1, PCGF4, RNF51
Target/Specificity The synthetic peptide sequence used to generate the antibody AP2513c was selected from the Center region of human BMI . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name BMI1
Synonyms PCGF4, RNF51
Function Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. In the PRC1 complex, it is required to stimulate the E3 ubiquitin-protein ligase activity of RNF2/RING2.
Cellular Location Nucleus. Cytoplasm.
Research Areas
Citations (0)

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Background

BMI is a component of the Polycomb group (PcG) multiprotein PRC1 complex, a complex required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. In the PRC1 complex, it is required to stimulate the E3 ubiquitin ligase activity of RNF2/RING2. BMI cooperates with the MYC oncogene to produce B-lymphomas.

References

Smith, K.S., et al., Mol. Cell 12(2):393-400 (2003).Xia, Z.B., et al., Proc. Natl. Acad. Sci. U.S.A. 100(14):8342-8347 (2003).Itahana, K., et al., Mol. Cell. Biol. 23(1):389-401 (2003).Dimri, G.P., et al., Cancer Res. 62(16):4736-4745 (2002).Bardos, J.I., et al., J. Biol. Chem. 275(37):28785-28792 (2000).

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$ 80.00
Cat# BP2513c
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