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CBX8 Antibody (N-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q9HC52
Clone Names 2121306
Peptide ID 2121306
Additional Information
Gene ID 57332
Other Names Chromobox protein homolog 8, Polycomb 3 homolog, Pc3, hPc3, Rectachrome 1, CBX8, PC3, RC1
Target/Specificity The synthetic peptide sequence used to generate the antibody AP2515a was selected from the N-term region of human CBX8 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name CBX8
Synonyms PC3, RC1
Function Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.
Cellular Location Nucleus.
Research Areas
Citations (0)

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Chromobox homolog 8 (CBX8 or Pc3) is a member of Drosophila Polycomb group gene family. The polycomb group (PcG) genes are essential for maintenance of appropriate expression patterns of developmental master regulators and thus are essential for proper development. Changes in expression of PcG proteins have been associated with cancer. CBX8 is involved in maintaining the transcriptionally repressive state of genes. It modifies chromatin, rendering it heritably changed in its expressibility. Structurally, CBX4 contains 1 chromo domain, which is 40 to 50 amino acids long.


Ota, T., et al., Nat. Genet. 36(1):40-45 (2004).Strausberg, R.L., et al., Proc. Natl. Acad. Sci. U.S.A. 99(26):16899-16903 (2002).Bardos, J.I., et al., J. Biol. Chem. 275(37):28785-28792 (2000).

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$ 80.00
Cat# BP2515a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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