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NMT2 Antibody (N-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession O60551
Other Accession NMT2_HUMAN
Clone Names 3082812
Additional Information
Gene ID 9397
Other Names Glycylpeptide N-tetradecanoyltransferase 2, Myristoyl-CoA:protein N-myristoyltransferase 2, NMT 2, Peptide N-myristoyltransferase 2, Type II N-myristoyltransferase, NMT2
Target/Specificity The synthetic peptide sequence is selected from aa 31~46 of human NMT2.
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name NMT2 {ECO:0000303|PubMed:9506952, ECO:0000312|HGNC:HGNC:7858}
Function Adds a myristoyl group to the N-terminal glycine residue of certain cellular and viral proteins (PubMed:25255805, PubMed:9506952). Also able to mediate N-terminal lysine myristoylation of proteins: catalyzes myristoylation of ARF6 on both 'Gly-2' and 'Lys-3' (PubMed:32103017). Lysine myristoylation is required to maintain ARF6 on membranes during the GTPase cycle (PubMed:32103017).
Cellular Location Cytoplasm. Membrane; Peripheral membrane protein
Research Areas
Citations (0)
citation

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Background

N-myristoyltransferase (NMT) catalyzes the reaction of N-terminal myristoylation of many signaling proteins. It transfers myristic acid from myristoyl coenzyme A to the amino group of a protein's N-terminal glycine residue. Biochemical evidence indicates the presence of several distinct NMTs, varying in apparent molecular weight and /or subcellular distribution. The predicted 498-amino acid of human NMT2 protein shares 77% and 96% sequence identity with human NMT1 and mouse Nmt2 comprise two distinct families of N-myristoyltransferases.

References

Lindwasser, O.W., et al., Proc. Natl. Acad. Sci. U.S.A. 99(20):13037-13042 (2002).Kolluri, S.K., et al., Cancer Res. 61(23):8534-8539 (2001).Shiraishi, T., et al., Biochem. Biophys. Res. Commun. 282(5):1201-1205 (2001).Ono, A., et al., J. Virol. 73(5):4136-4144 (1999).Paillart, J.C., et al., J. Virol. 73(4):2604-2612 (1999).

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$ 277.78
Cat# BP2520a
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