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CPT2 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P23786 |
|---|---|
| Other Accession | CPT2_HUMAN |
| Clone Names | 3090206 |
| Gene ID | 1376 |
|---|---|
| Other Names | Carnitine O-palmitoyltransferase 2, mitochondrial, Carnitine palmitoyltransferase II, CPT II, CPT2, CPT1 |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP2531b was selected from the C-term region of human CPT2 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | CPT2 (HGNC:2330) |
|---|---|
| Synonyms | CPT1 |
| Function | Involved in the intramitochondrial synthesis of acylcarnitines from accumulated acyl-CoA metabolites (PubMed:20538056, PubMed:24780397). Reconverts acylcarnitines back into the respective acyl-CoA esters that can then undergo beta-oxidation, an essential step for the mitochondrial uptake of long-chain fatty acids and their subsequent beta-oxidation in the mitochondrion. Active with medium (C8- C12) and long-chain (C14-C18) acyl-CoA esters (PubMed:20538056). |
| Cellular Location | Mitochondrion inner membrane; Peripheral membrane protein; Matrix side |
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Provided below are standard protocols that you may find useful for product applications.
Background
Carnitine palmitoyltransferase II precursor (CPT2) is a nuclear protein which is transported to the mitochondrial inner membrane. CPT2 together with carnitine palmitoyltransferase I oxidizes long-chain fatty acids in the mitochondria. Defects in this gene are associated with mitochondrial long-chain fatty-acid (LCFA) oxidation disorders.
References
Deschauer, M., et al., Mol. Genet. Metab. 75(2):181-185 (2002).Haap, M., et al., J. Clin. Endocrinol. Metab. 87(5):2139-2143 (2002).Britton, C.H., et al., Proc. Natl. Acad. Sci. U.S.A. 92(6):1984-1988 (1995).Verderio, E., et al., Hum. Mol. Genet. 4(1):19-29 (1995).Montermini, L., et al., Biochim. Biophys. Acta 1219(1):237-240 (1994).
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