|Other Names||Carnitine O-palmitoyltransferase 2, mitochondrial, Carnitine palmitoyltransferase II, CPT II, CPT2, CPT1|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP2531b was selected from the C-term region of human CPT2 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Cellular Location||Mitochondrion inner membrane; Peripheral membrane protein; Matrix side|
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Provided below are standard protocols that you may find useful for product applications.
Carnitine palmitoyltransferase II precursor (CPT2) is a nuclear protein which is transported to the mitochondrial inner membrane. CPT2 together with carnitine palmitoyltransferase I oxidizes long-chain fatty acids in the mitochondria. Defects in this gene are associated with mitochondrial long-chain fatty-acid (LCFA) oxidation disorders.
Deschauer, M., et al., Mol. Genet. Metab. 75(2):181-185 (2002).Haap, M., et al., J. Clin. Endocrinol. Metab. 87(5):2139-2143 (2002).Britton, C.H., et al., Proc. Natl. Acad. Sci. U.S.A. 92(6):1984-1988 (1995).Verderio, E., et al., Hum. Mol. Genet. 4(1):19-29 (1995).Montermini, L., et al., Biochim. Biophys. Acta 1219(1):237-240 (1994).
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