PPT2 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q9UMR5 |
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Other Accession | PPT2_HUMAN |
Clone Names | 3090808 |
Gene ID | 9374 |
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Other Names | Lysosomal thioesterase PPT2, PPT-2, 312-, S-thioesterase G14, PPT2 |
Target/Specificity | The synthetic peptide sequence used to generate the antibody AP2539b was selected from the C-term region of human PPT2 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | PPT2 |
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Function | Removes thioester-linked fatty acyl groups from various substrates including S-palmitoyl-CoA. Has the highest S-thioesterase activity for the acyl groups palmitic and myristic acid followed by other short- and long-chain acyl substrates. However, because of structural constraints, is unable to remove palmitate from peptides or proteins. |
Cellular Location | Lysosome. |
Tissue Location | Broadly expressed, with highest levels in skeletal muscle. |
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Provided below are standard protocols that you may find useful for product applications.
Background
PPT2 removes thioester-linked fatty acyl groups from modified cysteine residues in proteins and prefers the acyl groups palmitic and myristic acid over other long-chain acyl substrates. It is a glycosylated lysosomal protein and member of the palmitoyl-protein thioesterase family.
References
Clark, H.F., et al., Genome Res. 13(10):2265-2270 (2003).Calero, G., et al., J. Biol. Chem. 278(39):37957-37964 (2003).Soyombo, A.A., et al., Genomics 56(2):208-216 (1999).Soyombo, A.A., et al., J. Biol. Chem. 272(43):27456-27463 (1997).Aguado, B., et al., Biochem. J. 341 (Pt 3), 679-689 (1999).
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