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PPT2 Antibody (C-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q9UMR5
Other Accession PPT2_HUMAN
Clone Names 3090808
Additional Information
Gene ID 9374
Other Names Lysosomal thioesterase PPT2, PPT-2, 312-, S-thioesterase G14, PPT2
Target/Specificity The synthetic peptide sequence used to generate the antibody AP2539b was selected from the C-term region of human PPT2 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name PPT2
Function Removes thioester-linked fatty acyl groups from various substrates including S-palmitoyl-CoA. Has the highest S-thioesterase activity for the acyl groups palmitic and myristic acid followed by other short- and long-chain acyl substrates. However, because of structural constraints, is unable to remove palmitate from peptides or proteins.
Cellular Location Lysosome.
Tissue Location Broadly expressed, with highest levels in skeletal muscle.
Research Areas
Citations (0)
citation

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Background

PPT2 removes thioester-linked fatty acyl groups from modified cysteine residues in proteins and prefers the acyl groups palmitic and myristic acid over other long-chain acyl substrates. It is a glycosylated lysosomal protein and member of the palmitoyl-protein thioesterase family.

References

Clark, H.F., et al., Genome Res. 13(10):2265-2270 (2003).Calero, G., et al., J. Biol. Chem. 278(39):37957-37964 (2003).Soyombo, A.A., et al., Genomics 56(2):208-216 (1999).Soyombo, A.A., et al., J. Biol. Chem. 272(43):27456-27463 (1997).Aguado, B., et al., Biochem. J. 341 (Pt 3), 679-689 (1999).

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$ 277.78
Cat# BP2539b
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Availability: 2 weeks
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