|Other Names||Protein-S-isoprenylcysteine O-methyltransferase, Isoprenylcysteine carboxylmethyltransferase, Prenylated protein carboxyl methyltransferase, PPMT, Prenylcysteine carboxyl methyltransferase, pcCMT, ICMT, PCCMT|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP2543b was selected from the C-term region of human ICMT (C-term). A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Catalyzes the post-translational methylation of isoprenylated C-terminal cysteine residues.|
|Cellular Location||Endoplasmic reticulum membrane; Multi-pass membrane protein|
|Tissue Location||Ubiquitously expressed. Expressed at higher levels in the cerebellum and putamen than in other brain regions Abundant expression seen in the Purkinje cells and pontine neurons.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes the third of three enzymes that posttranslationally modify isoprenylated C-terminal cysteine residues in certain proteins and target those proteins to the cell membrane. This enzyme localizes to the endoplasmic reticulum. Alternative splicing results in two transcript variants encoding different isoforms.
Bergo, M.O., et al., J. Clin. Invest. 113(4):539-550 (2004).Ahmad, M., et al., Arterioscler. Thromb. Vasc. Biol. 22(5):759-764 (2002).Van Dessel, G.A., et al., Int. J. Biochem. Cell Biol. 34(5):477-486 (2002).Dai, Q., et al., J. Biol. Chem. 273(24):15030-15034 (1998).
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