|Other Names||Sulfotransferase 1C2, ST1C2, 282-, Sulfotransferase 1C1, SULT1C#1, humSULTC2, SULT1C2, SULT1C1|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP2602a was selected from the N-term region of human SULT1C1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of drugs, xenobiotic compounds, hormones, and neurotransmitters. May be involved in the activation of carcinogenic hydroxylamines. Shows activity towards p-nitrophenol and N-hydroxy-2-acetylamino-fluorene (N-OH-2AAF).|
|Tissue Location||Found in adult stomach, kidney and thyroid gland, and in fetal kidney and liver|
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The 296-amino acid human SULTC1 protein, so named on the basis of its significant homology to a rat hepatic cytosolic sulfotransferase ST1C1, catalyzes the sulfate conjugation of many drugs, xenobiotic compounds, hormones, and neurotransmitters, and may be involved in the activation of carcinogenic hydroxylamines. This enzyme also shows activity towards p-nitrophenol and N-hydroxy-2-acetylamino-fluorene (N-OH-2AAF). SULT1C1 is expressed as a 1.4-kb mRNA in adult human stomach, kidney, and thyroid, and in fetal kidney and liver. By functional characterization of recombinant protein, it has been shown that SULT1C1 catalyzes the sulfonation of p-nitrophenol and N-hydroxy-2-acetylaminofluorene, but not dopamine, 17-beta-estradiol, or dehydroepiandrosterone.
Mutat. Res. 482 (1-2), 27-40 (2001).Chem. Biol. Interact. 129 (1-2), 141-170 (2000).Genomics 65 (2), 157-165 (2000).Genomics 41 (3), 467-470 (1997).FASEB J. 11 (1), 3-14 (1997).
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