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SULT1C1 Antibody (N-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession O00338
Other Accession NP_789795
Clone Names 3120414
Additional Information
Gene ID 6819
Other Names Sulfotransferase 1C2, ST1C2, 282-, Sulfotransferase 1C1, SULT1C#1, humSULTC2, SULT1C2, SULT1C1
Target/Specificity The synthetic peptide sequence used to generate the antibody AP2602a was selected from the N-term region of human SULT1C1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name SULT1C2
Synonyms SULT1C1
Function Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of phenolic compounds. Does not sulfonate steroids, dopamine, acetaminophen, or alpha-naphthol (PubMed:9852044, PubMed:10783263, PubMed:10481272). Catalyzes the sulfonation of the carcinogenic N- Hydroxy-2-acetylaminofluorene leading to highly reactive intermediates capable of forming DNA adducts, potentially resulting in mutagenesis (PubMed:9852044).
Cellular Location Cytoplasm {ECO:0000250|UniProtKB:O46503}. Lysosome {ECO:0000250|UniProtKB:Q9WUW8}
Tissue Location Found in adult stomach, kidney and thyroid gland, and in fetal kidney and liver
Research Areas
Citations (0)
citation

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Background

The 296-amino acid human SULTC1 protein, so named on the basis of its significant homology to a rat hepatic cytosolic sulfotransferase ST1C1, catalyzes the sulfate conjugation of many drugs, xenobiotic compounds, hormones, and neurotransmitters, and may be involved in the activation of carcinogenic hydroxylamines. This enzyme also shows activity towards p-nitrophenol and N-hydroxy-2-acetylamino-fluorene (N-OH-2AAF). SULT1C1 is expressed as a 1.4-kb mRNA in adult human stomach, kidney, and thyroid, and in fetal kidney and liver. By functional characterization of recombinant protein, it has been shown that SULT1C1 catalyzes the sulfonation of p-nitrophenol and N-hydroxy-2-acetylaminofluorene, but not dopamine, 17-beta-estradiol, or dehydroepiandrosterone.

References

Mutat. Res. 482 (1-2), 27-40 (2001).Chem. Biol. Interact. 129 (1-2), 141-170 (2000).Genomics 65 (2), 157-165 (2000).Genomics 41 (3), 467-470 (1997).FASEB J. 11 (1), 3-14 (1997).

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$ 277.78
Cat# BP2602a
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