|Other Names||Sulfotransferase 1C4, ST1C4, 282-, Sulfotransferase 1C2, SULT1C#2, SULT1C4, SULT1C2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of drugs, xenobiotic compounds, hormones, and neurotransmitters. May be involved in the activation of carcinogenic hydroxylamines. Shows activity towards p-nitrophenol and N-hydroxy-2-acetylamino-fluorene (N-OH-2AAF).|
|Tissue Location||Expressed at high levels in fetal lung and kidney and at low levels in fetal heart, adult kidney, ovary and spinal chord|
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Provided below are standard protocols that you may find useful for product applications.
Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes a protein that belongs to the SULT1 subfamily, responsible for transferring a sulfo moiety from PAPS to phenol-containing compounds.
Freimuth, R.R., et al., Genomics 65(2):157-165 (2000).
Sakakibara, Y., et al., J. Biol. Chem. 273(51):33929-33935 (1998).
Weinshilboum, R.M., et al., FASEB J. 11(1):3-14 (1997).
Glatt, H., et al., Toxicol. Lett. 112-113, 341-348 (2000) (): ().
Glatt, H., Chem. Biol. Interact. 129 (1-2), 141-170 (2000) (): ().
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