CCND1 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q6FI00 |
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Clone Names | 80102162 |
Gene ID | 595 |
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Target/Specificity | The synthetic peptide sequence used to generate the antibody AP2612c was selected from the Center region of human CCND1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | CCND1 {ECO:0000313|EMBL:CAG38775.1} |
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Cellular Location | Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus membrane {ECO:0000256|ARBA:ARBA00004126} |
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Provided below are standard protocols that you may find useful for product applications.
Background
CCND1 belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of the gene encoding this protein, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis.
References
He,Y.Y., Cancer Res. 68 (10), 3752-3758 (2008)Marsit,C.J., Clin. Cancer Res. 14 (8), 2371-2377 (2008)Caldon,C.E., Cancer Res. 68 (8), 3026-3036 (2008)
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