|Other Names||Eomesodermin homolog, T-box brain protein 2, T-brain-2, TBR-2, EOMES, TBR2|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP2703a was selected from the N-term region of human EOMES. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Functions as a transcriptional activator playing a crucial role during development. Functions in trophoblast differentiation and later in gastrulation, regulating both mesoderm delamination and endoderm specification. Plays a role in brain development being required for the specification and the proliferation of the intermediate progenitor cells and their progeny in the cerebral cortex. Also involved in the differentiation of CD8+ T-cells during immune response regulating the expression of lytic effector genes.|
|Tissue Location||Expressed in CD8+ T-cells.|
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Provided below are standard protocols that you may find useful for product applications.
This protein is a member of a conserved protein family that shares a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. A similiar protein disrupted in mice is shown to be essential during trophoblast development and gastrulation.
Baala,L., Nat. Genet. 39 (4), 454-456 (2007)Intlekofer,A.M.,Nat. Immunol. 6 (12), 1236-1244 (2005)Kimura,N., Brain Res. Dev. Brain Res. 115 (2), 183-193 (1999)Yi,C.H.,Genomics 55 (1), 10-20 (1999)
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