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EOMES (TBR2) Antibody (N-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | O95936 |
|---|---|
| Clone Names | 6071519 |
| Gene ID | 8320 |
|---|---|
| Other Names | Eomesodermin homolog, T-box brain protein 2, T-brain-2, TBR-2, EOMES, TBR2 |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP2703a was selected from the N-term region of human EOMES. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | EOMES |
|---|---|
| Synonyms | TBR2 |
| Function | Functions as a transcriptional activator playing a crucial role during development. Functions in trophoblast differentiation and later in gastrulation, regulating both mesoderm delamination and endoderm specification. Plays a role in brain development being required for the specification and the proliferation of the intermediate progenitor cells and their progeny in the cerebral cortex. Also involved in the differentiation of CD8+ T-cells during immune response regulating the expression of lytic effector genes. |
| Cellular Location | Nucleus. |
| Tissue Location | Expressed in CD8+ T-cells. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
This protein is a member of a conserved protein family that shares a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. A similiar protein disrupted in mice is shown to be essential during trophoblast development and gastrulation.
References
Baala,L., Nat. Genet. 39 (4), 454-456 (2007)Intlekofer,A.M.,Nat. Immunol. 6 (12), 1236-1244 (2005)Kimura,N., Brain Res. Dev. Brain Res. 115 (2), 183-193 (1999)Yi,C.H.,Genomics 55 (1), 10-20 (1999)
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