|Other Names||Homeobox protein MSX-2, Homeobox protein Hox-8, MSX2, HOX8|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP2709a was selected from the N-term region of human Msx2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Acts as a transcriptional regulator in bone development. Represses the ALPL promoter activity and antogonizes the stimulatory effect of DLX5 on ALPL expression during osteoblast differentiation. Probable morphogenetic role. May play a role in limb-pattern formation. In osteoblasts, suppresses transcription driven by the osteocalcin FGF response element (OCFRE). Binds to the homeodomain-response element of the ALPL promoter.|
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Provided below are standard protocols that you may find useful for product applications.
Msx2 is a transcriptional repressor whose normal activity may establish a balance between survival and apoptosis of neural crest-derived cells required for proper craniofacial morphogenesis. This protein may also have a role in promoting cell growth under certain conditions and may be an important target for the RAS signaling pathways. Mutations in the Msx2 gene are associated with parietal foramina 1 and craniosynostosis type 2.
Shao,J.S., Ann. N. Y. Acad. Sci. 1117, 40-50 (2007)Han,J., Mech. Dev. 124 (9-10), 729-745 (2007)Ghassibe,M., Eur. J. Pediatr. 165 (10), 734-735 (2006)
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