|Other Names||Prohibitin, PHB|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP2710c was selected from the Center region of human PHB. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Prohibitin inhibits DNA synthesis. It has a role in regulating proliferation. As yet it is unclear if the protein or the mRNA exhibits this effect. May play a role in regulating mitochondrial respiration activity and in aging.|
|Cellular Location||Mitochondrion inner membrane.|
|Tissue Location||Widely expressed in different tissues.|
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Provided below are standard protocols that you may find useful for product applications.
Prohibitin is an evolutionarily conserved protein that is ubiquitously expressed. It is thought to be a negative regulator of cell proliferation and may be a tumor suppressor. Mutations have been linked to sporadic breast cancer. Prohibitin is expressed as two transcripts with varying lengths of 3' untranslated region.
Gregory-Bass,R.C., Int. J. Cancer 122 (9), 1923-1930 (2008)Ross,J.A., J. Biol. Chem. 283 (8), 4699-4713 (2008)White,J.J., Genomics 11 (1), 228-230 (1991)
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