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>   home   >   Products   >   Peptides   >   Blocking Peptides   >   HERV (ERVWE1) Antibody (Center) Blocking peptide   

HERV (ERVWE1) Antibody (Center) Blocking peptide

Synthetic peptide

Product Information
Primary Accession Q9UQF0
Clone Names 5121975
Peptide ID 5121975
Additional Information
Gene ID 30816
Other Names Syncytin-1, Endogenous retrovirus group W member 1, Env-W, Envelope polyprotein gPr73, Enverin, HERV-7q Envelope protein, HERV-W envelope protein, HERV-W_7q212 provirus ancestral Env polyprotein, Syncytin, Surface protein, SU, gp50, Transmembrane protein, TM, gp24, ERVW-1, ERVWE1
Target/Specificity The synthetic peptide sequence used to generate the antibody AP2716c was selected from the Center region of human ERVWE1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name ERVW-1
Synonyms ERVWE1
Function This endogenous retroviral envelope protein has retained its original fusogenic properties and participates in trophoblast fusion and the formation of a syncytium during placenta morphogenesis. May induce fusion through binding of SLC1A4 and SLC1A5 (PubMed:10708449, PubMed:12050356, PubMed:23492904).
Cellular Location Transmembrane protein: Cell membrane; Single-pass type I membrane protein Syncytin-1: Virion.
Tissue Location Expressed at higher level in placental syncytiotrophoblast. Expressed at intermediate level in testis Seems also to be found at low level in adrenal tissue, bone marrow, breast, colon, kidney, ovary, prostate, skin, spleen, thymus, thyroid, brain and trachea. Both mRNA and protein levels are significantly increased in the brain of individuals with multiple sclerosis, particularly in astrocytes and microglia
Research Areas
Citations (0)

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Many different human endogenous retrovirus (HERV) families are expressed in normal placental tissue at high levels, suggesting that HERVs are functionally important in reproduction. The protein, also known as syncytin, is expressed in the placental syncytiotrophoblast and is involved in fusion of the cytotrophoblast cells to form the syncytial layer of the placenta. This protein has the characteristics of a typical retroviral envelope protein, including a furin cleavage site that separates the surface (SU) and transmembrane (TM) proteins which form a heterodimer.


Oluwole,S.O., Amyotroph Lateral Scler 8 (2), 67-72 (2007)Gong,R., Cell. Physiol. Biochem. 20 (5), 517-526 (2007)Antony,J.M., AIDS Res. Hum. Retroviruses 22 (12), 1253-1259 (2006)

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$ 80.00
Cat# BP2716c
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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