NCLN Blocking Peptide (N-term)
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q969V3 |
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Gene ID | 56926 |
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Other Names | Nicalin, Nicastrin-like protein, NCLN |
Target/Specificity | The synthetic peptide sequence is selected from aa 321-335 of HUMAN NCLN |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | NCLN {ECO:0000303|PubMed:36261522, ECO:0000312|HGNC:HGNC:26923} |
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Function | Component of the multi-pass translocon (MPT) complex that mediates insertion of multi-pass membrane proteins into the lipid bilayer of membranes (PubMed:36261522, PubMed:32820719). The MPT complex takes over after the SEC61 complex: following membrane insertion of the first few transmembrane segments of proteins by the SEC61 complex, the MPT complex occludes the lateral gate of the SEC61 complex to promote insertion of subsequent transmembrane regions (PubMed:36261522). May antagonize Nodal signaling and subsequent organization of axial structures during mesodermal patterning, via its interaction with NOMO (By similarity). |
Cellular Location | Endoplasmic reticulum membrane; Single-pass membrane protein |
Tissue Location | Highly expressed in pancreas and skeletal muscle and, at lower levels, in heart. |
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Provided below are standard protocols that you may find useful for product applications.
Background
NCLN may antagonize Nodal signaling and subsequent organization of axial structures during mesodermal patterning.
References
Haffner,C., EMBO J. 23 (15), 3041-3050 (2004)
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