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DAAM1 Antibody (C-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q9Y4D1
Clone Names 6072346
Peptide ID 6072346
Additional Information
Gene ID 23002
Other Names Disheveled-associated activator of morphogenesis 1, DAAM1, KIAA0666
Target/Specificity The synthetic peptide sequence used to generate the antibody AP2720b was selected from the C-term region of humanAM1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name DAAM1
Synonyms KIAA0666
Function Binds to disheveled (Dvl) and Rho, and mediates Wnt- induced Dvl-Rho complex formation. May play a role as a scaffolding protein to recruit Rho-GDP and Rho-GEF, thereby enhancing Rho-GTP formation. Can direct nucleation and elongation of new actin filaments.
Cellular Location Cytoplasm. Note=Perinuclear
Tissue Location Expressed in all tissues examined.
Research Areas
Citations (0)

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Functions of the cell cortex, including motility, adhesion, and cytokinesis, are mediated by the reorganization of the actin cytoskeleton and recent evidence suggests a role for the Formin homology (FH) proteins in these processes. DAAM1 contains FH domains and belongs to a novel FH protein subfamily implicated in cell polarity. Wnt/Fz signaling activates the small GTPase Rho, a key regulator of cytoskeleton architecture, to control cell polarity and movement during development. Activation requires Dvl-Rho complex formation, an assembly mediated by DAAM1, which is thought to function as a scaffolding protein.


Liu,W., Proc. Natl. Acad. Sci. U.S.A. 105 (1), 210-215 (2008)Yamashita,M.,Genes Cells 12 (11), 1255-1265 (2007)Lu,J., J. Mol. Biol. 369 (5), 1258-1269 (2007)

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$ 80.00
Cat# BP2720b
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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