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|Other Names||Wnt inhibitory factor 1, WIF-1, WIF1|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP2723a was selected from the N-term region of human WIF1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Function||Binds to WNT proteins and inhibits their activities. May be involved in mesoderm segmentation.|
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Provided below are standard protocols that you may find useful for product applications.
WNT proteins are extracellular signaling molecules involved in the control of embryonic development. WIF1 is a secreted protein, which binds WNT proteins and inhibits their activities. This protein contains a WNT inhibitory factor (WIF) domain and 5 epidermal growth factor (EGF)-like domains. It may be involved in mesoderm segmentation. This protein is found to be present in fish, amphibia and mammals.
Elston,M.S., Endocrinology 149 (3), 1235-1242 (2008)Clement,G., Cancer Sci. 99 (1), 46-53 (2008)Chan,S.L., Lab. Invest. 87 (7), 644-650 (2007)
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