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NANOS2 Antibody (C-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession P60321
Clone Names 70920129
Peptide ID 70920129
Additional Information
Gene ID 339345
Other Names Nanos homolog 2, NOS-2, NANOS2, NOS2
Target/Specificity The synthetic peptide sequence used to generate the antibody AP2730b was selected from the C-term region of human NANOS2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms NOS2
Function Plays a key role in the sexual differentiation of germ cells by promoting the male fate but suppressing the female fate. Represses the female fate pathways by suppressing meiosis, which in turn results in the promotion of the male fate. Maintains the suppression of meiosis by preventing STRA8 expression, which is required for premeiotic DNA replication, after CYP26B1 is decreased. Regulates the localization of the CCR4-NOT deadenylation complex to P-bodies and plays a role in recruiting the complex to trigger the degradation of mRNAs involved in meiosis. Required for the maintenance of the spermatogonial stem cell population. Not essential for the assembly of P-bodies but is required for the maintenance of their normal state (By similarity).
Cellular Location Cytoplasm. Cytoplasm, P-body. Cytoplasm, perinuclear region. Note=Localizes at P-bodies during gonocyte development (By similarity). More abundant in perinuclear region of the cytoplasm of the germ cells of the adult testis
Tissue Location Testis and ovary. Expression found in several spermatogenic stages: in cells on the periphery of the tubules which could correspond to spermatogonia, in spermatocytes and in round spermatids (at protein level).
Research Areas
Citations (0)

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NANOS2 is required to support proliferation and self-renewal of proximal germ cells in males only. It probably regulates translation of specific mRNAs by associating with the 3'-UTR of mRNA targets. It is essential for spermatogonia formation.


Chang,H.R., Arch. Dermatol. Res. 295 (7), 293-296 (2003)Tsuda,M., Science 301 (5637), 1239-1241 (2003)Jaruzelska,J., Dev. Genes Evol. 213 (3), 120-126 (2003)

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$ 80.00
Cat# BP2730b
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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