|Other Names||Sprouty-related, EVH1 domain-containing protein 2, Spred-2, SPRED2|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP2732b was selected from the C-term region of human SPRED2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Tyrosine kinase substrate that inhibits growth-factor- mediated activation of MAP kinase.|
|Cellular Location||Membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle, secretory vesicle membrane; Peripheral membrane protein; Cytoplasmic side Cytoplasm. Note=Especially found in the cytoplasm of the stratum spinosum cells called membrane-coated granules|
|Tissue Location||Expressed in liver, skin, small intestine, salivary gland and prostate.|
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Provided below are standard protocols that you may find useful for product applications.
SPRED2 is a member of the Sprouty (see SPRY1; MIM 602465)/SPRED family of proteins that regulate growth factor-induced activation of the MAP kinase cascade (see MAPK1; MIM 176948) (Nonami et al., 2004 [PubMed 15465815]).
Lock,P., Biochem. Biophys. Res. Commun. 351 (4), 1018-1023 (2006)Yoshida,T., Oncogene 25 (45), 6056-6066 (2006)Bundschu,K., J. Biol. Chem. 280 (31), 28572-28580 (2005)
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