|Other Names||Microsomal glutathione S-transferase 1, Microsomal GST-1, Microsomal GST-I, MGST1, GST12, MGST|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP2750c was selected from the Center region of human MGST1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Has a wide substrate specificity.|
|Cellular Location||Microsome. Mitochondrion outer membrane; Peripheral membrane protein Endoplasmic reticulum membrane; Multi-pass membrane protein|
|Tissue Location||Highly expressed in liver.|
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Provided below are standard protocols that you may find useful for product applications.
The MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) family consists of six human proteins, two of which are involved in the production of leukotrienes and prostaglandin E, important mediators of inflammation. Other family members, demonstrating glutathione S-transferase and peroxidase activities, are involved in cellular defense against toxic, carcinogenic, and pharmacologically active electrophilic compounds.This gene encodes a protein that catalyzes the conjugation of glutathione to electrophiles and the reduction of lipid hydroperoxides. This protein is localized to the endoplasmic reticulum and outer mitochondrial membrane where it is thought to protect these membranes from oxidative stress.
Zhang,H., Int J Colorectal Dis 22 (10), 1185-1194 (2007)Prall,W.C., Mech. Ageing Dev. 128 (9), 503-510 (2007)Haines,J.L.,Invest. Ophthalmol. Vis. Sci. 47 (1), 329-335 (2006)
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