|Other Names||Protein numb homolog, h-Numb, Protein S171, NUMB|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP2756a was selected from the N-term region of human NUMB. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of neurogenesis. Also involved postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. May also mediate local repair of brain ventricular wall damage.|
|Cellular Location||Membrane; Peripheral membrane protein.|
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Provided below are standard protocols that you may find useful for product applications.
NUMB plays a role in the determination of cell fates during development. This protein, whose degradation is induced in a proteasome-dependent manner by MDM2, is a membrane-bound protein that has been shown to associate with EPS15, LNX1, and NOTCH1.
Colaluca,I.N., Nature 451 (7174), 76-80 (2008)Maiorano,E., Int J Immunopathol Pharmacol 20 (4), 779-789 (2007)Nishimura,T. Dev. Cell 13 (1), 15-28 (2007)
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