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B2M Antibody (C-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession P61769
Clone Names 80102136
Additional Information
Gene ID 567
Other Names Beta-2-microglobulin, Beta-2-microglobulin form pI 53, B2M
Target/Specificity The synthetic peptide sequence used to generate the antibody AP2771b was selected from the C-term region of human B2M. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name B2M (HGNC:914)
Function Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. Exogenously applied M.tuberculosis EsxA or EsxA-EsxB (or EsxA expressed in host) binds B2M and decreases its export to the cell surface (total protein levels do not change), probably leading to defects in class I antigen presentation (PubMed:25356553).
Cellular Location Secreted. Cell surface. Note=Detected in serum and urine (PubMed:1336137, PubMed:7554280). {ECO:0000269|PubMed:7554280, ECO:0000269|Ref.6}
Research Areas
Citations (0)
citation

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Background

Beta-2-microglobulin is a serum protein found in association with the major histocompatibility complex (MHC) class I heavy chain on the surface of nearly all nucleated cells.

References

Sakata,M., J. Mol. Biol. 382 (5), 1242-1255 (2008)Huang,W.C., Clin. Cancer Res. 14 (17), 5341-5347 (2008)Gattoni-Celli,S., Cancer Res. 52 (5), 1201-1204 (1992)

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$ 277.78
Cat# BP2771b
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Availability: 2 weeks
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