AASS Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q9UDR5 |
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Clone Names | 80109101 |
Gene ID | 10157 |
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Other Names | Alpha-aminoadipic semialdehyde synthase, mitochondrial, LKR/SDH, Lysine ketoglutarate reductase, LKR, LOR, Saccharopine dehydrogenase, SDH, AASS |
Target/Specificity | The synthetic peptide sequence used to generate the antibody AP2779c was selected from the Center region of human AASS. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | AASS (HGNC:17366) |
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Function | Bifunctional enzyme that catalyzes the first two steps in lysine degradation. |
Cellular Location | Mitochondrion. |
Tissue Location | Expressed in all 16 tissues examined with highest expression in the liver |
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Provided below are standard protocols that you may find useful for product applications.
Background
AASS is a bifunctional enzyme that catalyzes the first two steps in the mammalian lysine degradation pathway. The N-terminal and the C-terminal portions of this enzyme contain lysine-ketoglutarate reductase and saccharopine dehydrogenase activity, respectively, resulting in the conversion of lysine to alpha-aminoadipic semialdehyde. Mutations in the gene encoding this protein are associated with familial hyperlysinemia.
References
Sacksteder,K.A., Am. J. Hum. Genet. 66 (6), 1736-1743 (2000)
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